Polymorphic Symbionts as Potential Cofactors in Cancer Processes

Copyright 1997 by Karl Windstosser
(Explore Issue: Volume 7, Number 6)

1915

G. Fichera and Citelli (Milan) described "bacterial form elements" in human tumors; after 1925, this included various developmental phases of these in coccal and rod form. It is not clear whether Fichera produced a therapeutic agent from this -- which he designated as "Oncovaccina" -- or whether this name applied to an extract derived from sheep spleen, thymus, duodenum, lymph glands and bone marrow, which Fichera injected his patients with beginning about 1934. That would make this researcher -- at about the same time as Niehans -- one of the founders of organocellular or cytoplasmatic therapy, which is based on the empirical fact that sheep are the only mammals that are never (or extremely rarely) infested with cancer and that malignant vaccination tumors are just as unlikely to be transferable to them. This is especially true of the younger animals and lambs. We now know that the spleen, thymus and lymph glands exercise central functions in defensive and regulatory processes.

Somewhat later, Clara Jolles-Fonti (1954) and Guarnieri silently took over Fichera's ideas and therapy and added their own work to it. The ingredients of the preparation were simplified, initially to a combination of liver, spleen and duodenal extracts, and, finally, just liver and spleen. In this form, Permicutan (now biosyn.) took over production from Guarnieri in 1950. One milliliter of the preparation "Factor AF 2 Guarnieri" contains the extract from 7 grams liver and 3 grams spleen. The preparation has earned a good reputation in the field of holistic tumor therapy, despite the omission of the thymus component.

Publication

Title and contents unknown, perhaps with reference to the microbial results. Springer Verlag, Berlin / Heidelberg / Tokyo 1934.

1916

Günther Enderlein (1872-1968), biologist and zoologist, professor and curator at the Zoological Museum of the University of Berlin, first presented his revolutionary reconfiguration of bacteriology (developed during the war years -- he had been an army bacteriologist) to the Society of Friends of Natural-Science Research [Gesellschaft Naturforschende Freunde]. Because of war-related problems, his book Bacterial Cyclogeny. Prolegomena to Investigations into the Structure, Sexual and Asexual Reproduction and Development of the Bacteria, finished in the same year, was not able to be printed and published until 1925. Ever since Cohn (1870) and Koch (1876), bacterial monomorphism had become dogma, even though this idea had at first only had provisional status, to provide a framework for additional research. Even its promulgators continued to report casually on morphological variants of the microbes they observed -- and, in the foreword to his Bacterial Cyclogeny, Enderlein cites a series of predecessors and contemporaries who agreed with the generally postulated and concretely described process of the developmental cycle. In his tireless studies and interpretations, he found the explanation for many controversial microbial findings -- many first described by him, in part heterogeneous, in part identical -- as well as the key to many hitherto (and to some extent to this day) scientifically unexplained processes in pathogenesis and diseases transmission, healing and immunity.

According to Enderlein, all microbes go through a species-specific cycle, which bacteriological theory accepts as quite self-evident for malaria, but which to this day it resists acknowledging for bacteria and fungi, even though there is no exception in the whole wide world to the law of eternal change and the unity of the macrocosm with the microcosm.

"Cyclogeny" means the transformation and migration of all pathogenic and apathogenic germs through all phases (valences) from the limits of the visible and smaller -- the viral region -- on through the higher-valence phases of the textbook coccal and rod forms and up to the culminant phases of fungi and their mycelia. In this, the bacterial nucleus plays an important role, which, though Enderlein was aware of it, was not correctly interpreted as to function. Its reduplication corresponds to the length of the bacterial body. According to Enderlein's "Anartatic Fundamental Law", valence increase depends on the prevailing pH of the blood or tissues. The bacteria multiply -- and this, too, was one of Enderlein's fundamental insights -- either asexually by fission or budding (Auxanogeny) or sexually after preliminary nuclear fusion (Probaenogeny). The latter is always the prerequisite for phasal development upward or downward. The principle of polymorphism and sexual -- i.e. by means of nuclear fusion -- reproduction of bacteria was confirmed 40 years after Enderlein by the Nobel Prize laureates Lederberg, Taumg and Hayes (cited in Seeger, P. G.: Immune Processes and Cancer [Immungeschehen und Krebs] Semmelweis Verlag, Hoya). Before Enderlein, Mori (1910) had already supported this idea.

Out of the many concepts which Enderlein created for his theory, we can here only mention those which are of specific significance for oncological considerations. But this terminology was necessary and justified, since to go back to the usual terminology of orthodox bacteriology or to the nomenclature of the microbe researchers before Enderlein would only have given rise to more new misunderstandings or misinterpretations.

Enderlein designated the smallest and lowest bacterial stage as Protit. It consists of the bare nucleus (Mych) with no protoplasmic coat (Trophosom). One-dimensional reproduction leads to the formation of extremely fine threadlets, or Filits, two- and three-dimensional reproduction to Symprotits. In all, these 3 phases represent Chondritosis, within which a continuously alternating phase-change takes place. Chondrits are in the virus size range (15-300 nm) and are barely visible in the darkfield. Bacteriophages -- Enderlein's interpretation of which differs radically from the orthodox view -- also belong to this stage. Bacterial flagella are likewise Filits.

Higher developmental stages arise -- always dependent on environmental conditions -- through the formation of double- and multiple-nucleus cells with Trophosomes, in which each reduplication of the nuclei corresponds to the next higher stage, or Valence, of the Endobiont. The Enderleinian terms are, in sequence: Basit, Phytit, Rhabdit, Linit, Ascit, Synascit and -- the highest developmental form (Culminant) -- Amoebit. This represents the fully-developed fungus with all its typical characteristics, flagellum, mycelium and spore formation.

 

Besides the clarification of these morphological phenomena, Enderlein succeeded in identifying the most important vertebrate (but not invertebrate!) symbiont as Mucor racemosus Fresen 1870 in all of its stages from virus to fungus. In the Chondrit stage (see above), it lives as a physiological and innocuous -- probably in fact even useful -- symbiont in the blood and tissue of healthy people. However, as soon as the biochemical equilibrium changes, the Chondrits ascend to the higher phases or valences and in the process take on pathogenic characteristics. This applies to all civilization-induced diseases, particularly cancer. One can thus designate it as "obligate Mucor parasitism".

Retrograde development from higher to lower valences also takes place exclusively via the sexual route by means of nuclear fusion among Chondrits present in sufficient number. This process is blocked in sick persons. To this end, Enderlein developed Chondritin, with which a chain-reaction-like retrograde development of the pathogenic valences is set into motion. Dealing with the resulting mass of Protits is furthered with the aid of a serum derived from rabbits injected with higher valences and Protits.

The hematological changes associated with phasal and virulence increase manifest themselves -- aside from the rise in pH -- in increased (up to 100%) infestation both of erythrocytes and neutrophilic leukocytes as well as plasma with higher-valence Endobionts which present themselves to the eye morphologically as Symprotits, Symplasts, Basits, Ascits, etc. The erythrocytes, normally the storage depot of dormant symbionts, often take on the so-called burr-cell form, which the orthodox medical laboratories don't know what to do with. These are the microelements, appearing everywhere and active in full virulence. Some of these developmental stages are illustrated in the excellent photomicrographic reproductions in the two discussed books by Bleker and Haring (p. 15ff).

The anemia which often accompanies preliminary and early stages of malignancies is likewise explainable along these lines. The alert observer will not miss the phantom corpuscles, which only appear in the darkfield and which signalize the progressive Endobiont virulence which drives the destructive process. Now, it must be kept in mind that certain stages of this blood infestation can also appear in cases of other chronic and consumptive diseases, i.e. not just cancer and pre-cancerous processes, for example PcP, Hepatitis, MS, radiation and chemotherapy damage, focal diseases (especially in the teeth) etc. With a balanced alkaline diet, cleansing, holistic change therapy and sensible use of Enderlein preparations, these conditions -- even in cases of incipient or early-stage malignancies -- can often be halted or rolled back.

In 1932, Enderlein discovered the second facultative pathogen (unlike the Mucor symbiosis, however, not physiologically endobiotic), the black-spored mold Aspergillus niger van Tieghen, which, in its entire polymorphism and phase-dependent pathology, is the tuberculosis germ. Fontes (1910) provided the proof of this by transmitting the disease by means of bacterium-free filtrates. The Chondrit and Basit phases give rise to clinical pictures in man which were given all sorts of names by Enderlein's contemporaries -- such as scrofula, lymphatism, camouflaged tuberculosis (Patromikolas), masked tuberculosis (Willy Bircher), certain rheumatic forms (Poncet), tuberculotoxicosis and paratuberculosis. These also include Much's granules and Spengler's fragments. Other researchers have dedicated themselves to the therapeutic exploitation of these phenomena; these include Pirquet, Ponndorf and the above-mentioned Spengler (see 1902).

The Basit, Linit and Ascit stages of Aspergillus are the short and long rod forms of Sclerothrix tuberculosis Koch 1882, solid and not acid-resistant, whose culturing in all phases from s on up to the spore-forming Aspergillus is described accurately by Enderlein.

For therapizing tubercular and pretubercular diseases, Enderlein recommended various preparations, each available in various strengths, which can be administered subcutaneously, intramuscularly or orally, depending on the clinical picture:

1. Stabilized -- i.e. apathogenic -- Aspergillus or tuberculosis Chondritin with mode of action as described for the Endobiont's Chondritin.
2. The caretta Chondritin as cycle phase of the culturing of Sclerothrix antituberculosis Friedmann 1920, the agent of tuberculosis in the sea turtle Thalassochelis caretta. It is not pathogenic to man, but instead has a therapeutic effect like a homeopathic nosode in cases of human tuberculosis. Friedrich Franz Friedmann, who had to endure many attacks and much defamation in his life, deserves our thanks for his research and development of this therapeutic agent, which has fallen into obscurity only because of the chemotherapeutic treatment of tuberculosis.
3. The vaccines of Sclerothrix tuberculosis Koch, containing higher valences than the Chondritin.
4. The sea turtle tuberculosis vaccine, acid-resistant and non-acid-resistant.
5. The tuberculosis sera of rabbits that have been immunized against Sclerothrix tuberculosis Koch. Mode of action as per the Endobiont sera.
6. For all diseases which are, simultaneously or serially, of an Endobiontic or tuberculous nature, the Pliogen-Chondritin consisting of Mucor and Aspergillus Chondrites.

All of the isopathic preparations developed by Enderlein were produced under his personal supervision in his laboratory in Hamburg/Aumühle until shortly before his death. In 1975, the firm of SANUM-Kehlbeck (Hoya) acquired the production license and took over the business. The old, instructive preparation names were changed and many new agents (not from Enderlein) were added. Information and pertinent literature can be requested from the above-named company or from the associated publishing arm, Semmelweis Verlag.

Besides these preliminary research results and their therapeutic consequences for the Mucor and Aspergillus cycles, Enderlein published, after 1937, his ideas concerning the cancer-specific or carcinogenic properties of the higher developmental stages of the Mucor Endobiont. His argument is structured as follows:

1. Human blood is not sterile, as had been previously assumed, but rather harbors in all cases a minuscule parasite. It had not been discovered previously because it exists there primarily in an unusual and hitherto not described form, namely in the submicroscopic Protit stage. This most primitive developmental stage is of the same size order as viruses, which, according to Enderlein, are likewise to be ascribed to the species-specific cycle. The apparent sterility of standard blood cultures is explained by the fact that these stages in their parasitical property can only be cultured with great difficulty on artificial culture media, and only develop very slowly and poorly. However, sterilely drawn and incubated blood, or simply in blood maintained at room temperature, develops lively growth after a few weeks.

2. The parasite's life in the erythrocytes can be detected in fresh blood through its germination into free Chondrits or Symprotits in blood serum.

3. The relationship of the infection of the erythrocytes to cancer turns out to depend on the following factors:

a) Number of infected erythrocytes and phantom corpuscles;
b) Number of parasites in each infected erythrocyte;
c) Dynamovalence or size of the erythrocyte inclusions.

4. The bacterial form in the blood demonstrates, by its lively mobility, its existence as a special life-form in native preparation.

5. Free and enclosed (in nucleus or cell plasma) Symprotits and Symprotit barbells can also be found in the tumor, usually in enormous numbers.

6. Bacterial rods are also found -- although seldom -- growing out of the tumor cells.

7. Higher bacterial structural forms such as Cystits, Thecits, etc. can also be culturally obtained in blood (or nutrient glucose broth, etc.) and are massively present in tumors, either free or in cell bodies.

8. In sectioned tumors, one finds the highest forms observed in the human body of the parasite's developmental series, namely as fungal mycelium (Developmental History of the Bacteria [Entwicklungsgeschichte der Bakterien], Vol. 1 Number 3).

Enderlein included an aphorism of Lao-Tse's in some of his studies, which applies precisely to the Bacterial Cyclogeny he created: "When things have unfolded to their fullest development, they always return to their roots."

Publications

Of Enderlein's numerous scientific writings -- all together, they number over 500, of which 377 cover entomological topics in the years 1891 to 1942 -- we can here mention only those which are concerned with Endobiosis research and bacterial polymorphism. A complete listing of these, as well as of the contributions of other authors on the same topic, was put out in the sixties by the AKMON Verlag, at that time situated in Aumühle near Hamburg. In addition, we would like to call attention to the reprints listed here of some of Enderlein's and other pertinent publications, published by the Semmelweis Verlag in Hoya.

"Basic Elements of the Comparative Morphology and Biology of Bacteria." [Grundelemente der vergleichenden Morphologie und Biologie der Bakterien] Session Reports of the Society of Friends of Natural-Science Research [Sitzungsberichte der Gesellschaft der Naturforschenden Freunde], Berlin 1916 (provisional presentation of the concepts of "Bacterial Cyclogeny").

Bacterial Cyclogeny. Prolegomena to Investigations into the Structure, Sexual and Asexual Reproduction and Development of the Bacteria. [Bakterien-Cyclogenie. Prolegomena zu Untersuchungen über Bau, geschlechtliche und ungeschlechtliche Fortpflanzung und Entwicklung der Bakterien] Verlag Walter de Gruyter & Co., Berlin/Leipzig 1925. Reprinted by: Semmelweis Verlag, Hoya 1980. Translated into French by Dr. G. Langevine, Paris.

"Concerning the Pliocyclody of Bacteria. The Biological Significance of Bacterial Gonits, Gonidies and Cystits." Lectures, ref. in: Session Reports of the Society of Friends of Natural-Science Research [Sitzungsberichte der Gesellschaft der Naturforschenden Freunde], Berlin 1981.

"Conclusions from the Definitive Unmasking of Monomorphism as a Specious Dogma." [Folgerungen aus der endgültigen Entlarvung des Monomorphismus als spekulatives Dogma] Archive for the Developmental History of Bacteria [Archiv für Entwicklungsgeschichte der Bakterien] Vol. 1 Nr. 1, p. 162ff. (1933).

"The End of the Cell's Reign as the Ultimate Biological Unit." [Das Ende der Herrschaft der Zelle als letzte biologische Einheit] Archive for the Developmental History of Bacteria [Archiv für Entwicklungsgeschichte der Bakterien] Vol. 1 Nr. 2, p. 171ff. (1933).[Translated and published in Explore! for the Professional, Volume 6, #1 (1995)]

"The Cycle of the Cancer Agent, Mucor neoformans." [Der Kreislauf der Krebs-Urhebers, Mucor neoformans] (Doyen 1902) Archive for the Developmental History of Bacteria [Archiv für Entwicklungsgeschichte der Bakterien] Vol. 1 Nr. 8, p. 183ff. (1937).

"On the Hypotheses Concerning the Parasitical Nature of Oncogenesis on the one Hand and the Knowledge Developed over the Preceding Century and a Half concerning the Parasitical Nature of Cancer on the Other Hand." [Zu den Hypothesen über die parasitäre Krebsentstehung einerseits und den seit eineinhalb Jahrhunderten entwickelten Erkenntnissen der parasitären Krebsnatur andererseits] Folk Medicine 3[Volksheilkunde] (1949).

"On the Source of all Chronic Diseases." [Vom Urheber aller chronischen Erkrankungen] Folk Medicine 8[Volksheilkunde] (1955).

"On the Nature of Chronic Diseases, Specifically of Cancer and Glandular Cancer." [Über das Wesen der chronischen Erkrankungen, speziell von Krebs und Drüsenkrebs] Private Clinic and Sanatorium 4 [Privatklinik und Sanatorium] (1955).

Periodicals edited and published by Enderlein

Archive for the Developmental History of Bacteria [Archiv für Entwicklungsgeschichte der Bakterien] Vol. 1 Numbers 1-4; Vol. 2 Nr. 1. Verlag Erna Enderlein, Berlin 1931-1940, AKMON Verlag 1941-1972.

Immunbiologica. Writings on Immunobiological Methods of Fighting Disease. [Immunbiologica. Schriftenreihe über immunbiologische Krankheitsbekämpfung] Vols. 1-4: Siebeneicher Verlag, Berlin/Frankfurt 1946-1950; Vols. 5-6: IBICA Verlag, Aumühle near Hamburg 1954.

AKMON -- Elements of Complete Health and Akmosophy [AKMON -- Bausteine zur Vollgesundheit und Akmosophie.] Vol. 1/1955; Vol. 2/1957 (both IBICA Verlag, Aumühle near Hamburg); Vol. 3/1959 (AKMON Verlag, Aumühle near Hamburg). This has been reprinted by Semmelweis Verlag, Hoya 1980. It contains 23 articles by Enderlein, 12 by other authors.

Folia Isopathica. Vol. 1/1961 (improved new edition 1970), AKMON Verlag, Aumühle near Hamburg.

Relevant titles in the complete bibliography: [12, 17, 32-34, 46, 77, 90, 103, 106, 107, 118, 133, 139, 149, 150, 196, 197-199, 201].

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