SANUM Pharmaceuticals: The PLEO SAN Preparations
Polysaccharides for Haptenic Therapy

(Explore Issue: Volume 10, Number 6)

Introduction

For many diseases, a pathogen's toxins can still be present after the germ itself has been eliminated, thus perpetuating the disease. In fact, the toxins might be the sole disease-causing agent. To protect themselves from their own toxins, pathogens produce specific polysaccharides (termed antigen absorbers by CORNELIUS) designed to bind the pathogen's own toxins or antigens, preventing them from becoming active. Moreover, viruses, bacteria, plants and animals know how to store and communicate information with the aid of saccharides. The code laid down in this language is thus able to influence a multitude of regulatory processes in the host organism.

Furthermore, the low-molecular-weight polysaccharides represent haptens, which ­ when coupled to a higher-molecular-weight carrier (e.g., protein) ­ can stimulate cellular and humoral defenses. Bacterial toxins released during earlier infections and not eliminated from the body due to immune-system deficiencies can be bound by haptens, and thus represent an antigen. This antigen is capable of stimulating the immune system by activating the T lymphocytes, ultimately leading to elimination of the bacterial toxins.

The following haptens are available as PLEO™ SANS Preparations in homeopathic dilutions:
NAME	POTENCY	SOURCE
PLEO™ SAN ACNE	X6/X5 Drops/Oral Sips	Propionibacterim acnes
PLEO™ SAN BRUCEL	X6 Drops/Oral Sips	Brucella melitensis
PLEO™ SAN CAND	X6/X5 Drops/Oral Sips	Candida albicans
PLEO™ SANS COLI	X6/X7 Drops/Oral Sips	Escherichia coli
PLEO™ SAN KLEBS	X6 Drops/Oral Sips	Klebsiella pneumoniae
PLEO™ SAN MYC	X6/X5 Drops/Oral Sips	Mycobacterium bovis
PLEO™ SAN PROT	X6/X7 Drops/Oral Sips	Proteus vulgaris
PLEO™ SAN PSEU	X6/X5 Drops/Oral Sips	Pseudomonas aeruginosa
PLEO™ SAN SALM	X6 Drops/Oral Sips	Salmonella enteriditis
PLEO™ SAN SERRA	X6/X5 Drops/Oral Sips	Serratia marcescens
PLEO™ SAN STAPH	X6/X5 Drops/Oral Sips	Staphylococcus aureus
PLEO™ SAN STREP	X6/X5 Drops/Oral Sips	Streptococcus pyogenes
PLEO™ SAN TRICH	X6/X5 Drops/Oral Sips	Trichophyton verrucosum

Production of PLEO™ SANS (Sanukehls)

The initial materials for the various PLEO™ SANS are dead cells of the corresponding bacterial or fungal types. Using a painstaking extraction process, the polysaccharides necessary for haptenic therapy are dissolved out of the organism's cell walls. Due to differences in the fine structure of these polysaccharides in each bacterial or fungal type, this results in a large number of antigen variations.

In the extraction process, the polysaccharides are separated out from undesired proteins, as well as from lipid A, which is also a cell-wall component in gram-negative bacteria. The protein could trigger an allergic reaction, while lipid A is responsible for the toxic effect of the lipopolysaccharides (endotoxins) of gram-negative bacteria.

Polysaccharides from microorganisms are nontoxic to the host organism. For haptenic therapy with PLEO™ SANS, the extracted polysaccharide extract is homeopathically potentiated; the end result is largely free of proteins and endotoxins. Therefore, allergic and fever reactions to the use of PLEO™ SANS are unlikely.

Using PLEO™ SANS

Because of their effect in the organism, the PLEO™ SAN Preparations are utilized in the following areas:

1. Specific Terrain Cleansing

Specific terrain cleansing of microorganisms or their metabolic products is possible with the aid of the PLEO™ SAN Preparations in conjunction with microbiological or mycological findings. In addition, the corresponding PLEO™ SAN may be used against infections with similar pathogens.

Administering specific polysaccharides communicates specific information to the host organism, which it needs to regulate its symbiotic equilibrium with the microorganisms in question.

2. Stimulating the Immune System and Eliminating Reaction Blockages

After binding to a carrier molecule in the organism, haptens can trigger a humoral as well as a cellular immune response. These mechanisms neutralize and eliminate microbial antigens. Introducing the PLEO™ SAN structures to the body very quickly leads to immune-complex formation using the immunoglobulins present. This substance presumably functions as an immune modulator which effects a correction of immune-regulatory imbalances and develops its effect, for example, via induction of cytokines, particularly GM-CSF and IL-10. Based on investigations into the effects of PLEO™ SAN Pseu, it was possible to derive, in an immunologically substantial manner, that long lasting reaction blockages (e.g. as a consequence of treatment with corticosteroids) in cancer patients, or in cases of immune-system suppression, can be eliminated with the aid of the stimulating effect of SANUM Pharmaceuticals.

3. Hyposensitization

Haptens can also bind the antibodies or circulating immune complexes created to counteract the corresponding complete antigen. These antibodies (IgG) exhibit a blocking activity to allergic reactions that is transmitted by another antibody class (IgE). As hyposensitization continues to develop, the proportion of IgG often increases, while the concentration of IgE in the blood serum falls off.

4. Intermediate Agents when Treating with Nosodes

This effect is based on the absorption of the pathogenic antigens or toxins. Severe initial deterioration or antigen blockages are alleviated or eliminated by PLEO™ SAN Preparations.

 

5. As a Pharmaceutical for Individual Clinical Indication (see also Repertorium of the SANUM Pharmaceuticals, pp. 207-258)

Usage (Drops)

Take: for acute conditions, 5-10 drops every 12-24 hours; for chronic illnesses, 10 drops every other day

As an embrocation: 5-10 drops every 1 or 2 days at the site of the disease or in the bend of the elbow. After 8 months, therapy should be discontinued for several months.

Usage (oral sips)

1 ml 1-3 times per week

Side effects
The presence of certain specific organic components can, in rare cases, trigger hypersensitivity reactions.

PLEO™ SAN Acne

Active agent: Propionibacterium acnes
Nosodes: Corynebacterium acnes
Naturopathically documented areas of application: Acne Conglobata, rheumatoid arthritis

PLEO™ SAN Brucel

Active agent: Brucella melitensis
Nosodes: Brucella abortus
Naturopathically documented areas of application: Myalgia, subacute rheumatoid arthritis, intermittent fever

PLEO™ SAN Cand

Active agent: Candida albicans
Nosodes: Monilia albicans
Naturopathically documented areas of application: Oral diseases (stomatitis, gingivitis, perleche, aphthous ulcers), spasmodic. Painful small intestine, colitis, constipation after treatment with antibiotics, allergic asthma, inflammation of the vulva, vulvovaginitis, Crurosis vulvae, rectilinear fissural skinfold or mucous-membrane eczema, interdigital excema of the hands or feet, dermatosis after treatment with antibiotics

PLEO™ SAN Coli

Active agent: Escherichia coli
Nosodes: Bac. coli
Naturopathically documented areas of application: Cholangitis, cholecystitis, gastroenteritis, colitis, pyelonephritis, spermatocystitis. Epididymitis, cystitis, prostatitis, salpingitis, metritis, vaginitis

PLEO™ SAN Klebs

Active agent: Klebsiella pneumoniae
Nosodes: Klebsiella pneumoniae
Naturopathically documented areas of application: For supportive therapy during or after Friedlander's pneumonia; in cases of silicosis, pneumoconiosis, bronchiectasis, bronchial asthma; as an adjuvant in cases of acute influenza, pleuritis, pneumonia; for therapeutic injury after Antibiotic therapy

PLEO™ SAN Myc

Active agent: Mycobacterium bovis
Nosodes: Tuberculinum bovis
Naturopathically documented areas of application: Aphonia, bronchial asthma, cardiac arrhythmia, arthritis, juvenile acne, cholecystitis, cystopyelitis, eczema with fissures, enterocolitis, hordeolum, hydrocele, conjunctivitis, keratitis, headaches, laryngeal ulcer, cardialgia, Lupus erythematosus, metritis, nephritis, otitis, osteochondrosis, pleuritis, psoriasis, rhinitis, ventricular or duodenal ulcers, urticaria

PLEO™ SAN Prot

Active agent: Proteus vulgaris
Nosodes: Bac. proteus
Naturopathically documented areas of application: gastroenteritis, peritonitis, cystopyelitis, puerperal sepsis, otitis, gangrenous pulmonary processes, osteomyelitis, abnormal intestinal bacterial flora after antibiotic therapy, peripheral circulatory disorders, ventricular or duodenal ulcers, hematemesis, angio-neurotic edema, Meniere's disease, herpes

PLEO™ SAN Pseu

Active agent: Pseudomonas aeruginosa
Nosodes: Bac. pyocyaneus
Naturopathically documented areas of application: Infectious and allergic dermatitis, pruritus, insect bites, angioneurotic edema collagen disease, arthropathic fibrositis, keloids, Ulcus cruris, burns, bronchial asthma otitis, sinusitis, pharyngitis, chronic bronchitis, hay fever.

PLEO™ SAN Salm

Active agent: Salmonella enteritidis
Nosodes: Bac. gartner
Naturopathically documented areas of application: Growth inhibition, chronic pancreatitis, enterobiasis (oxyuriasis), chronic gastroenteritis, celiac disease, furunculosis, rheumatic fever.

PLEO™ SAN Serra

Active agent: Serratia marcescens
Nosodes: Enterococcinum
Naturopathically documented areas of application: In nosocomial infections with Serratia marcescens.

PLEO™ SAN Staph

Active agent: Staphylococcus aureus
Nosodes: Staphylococcus aureus
Naturopathically documented areas of application: Folliculosis, furunculitis, impetigo, blepharitis, hordeolum, tarsal cyst, angina otitis, sinusitis, mastoiditis, meningitis, osteomyelitis, nephritis, urogenital staphylococcal infections.

PLEO™ SAN Strep

Active agent: Streptococcus pyogenes
Nosodes: Streptococcus pyogenes
Naturopathically documented areas of application: Alopecia, Angina tonsillaris, cardialgia, eczema, endocarditis, myocarditis pericarditis, empyema, puerperal mastitis, migraine, osteomyelitis, Otitis media phlegmona, chronic rheumatoid arthritis

PLEO™ SAN Trich

Active agent: Trichophyton verrucosum
Nosodes: Trichophyton verrucosum
Naturopathically documented areas of application: Mycoses of the hairs, skin, nails, tinea, trichophytosis

 

Bibliography

• Cornelius, P. (1990): Nosoden und Begleittherapie (Nosodes and Adjuvant Therapy). Pflaum Verlag, Munich.
• Harann, J. (1998): Das Sanum-Praparat PLEOTM San Brucel (The Sanum Preparation PLEOTM San Brucel). Sanum-Post 42.
• Kramer, S. (1997): "Leukozytopenie" (Leukocytopenia). Gesundes Leben (Living Healthy) 4:70.
• Kunze, R. and J. Harann (1997): "Das immunologische Profil von PLEOTM San Pseu" (The Immunological Profile of PLEOTM San Pseu). Erfahrungsheilkunde (Empirical Medicine) 3: 181-88.
• Kunze, R. and J. Harann (1997): "Aufhebung hydrocortisonbedingter Immunsupporession" (Elimination of Hydrocortisone-Induced Immune Suppression). Sanum-Post 41.2-6.

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