On the Diagnosis and Management of Neurocutaneous Syndrome (NCS),
A Toxicity Disorder from Dental Sealants

© Copyright 2003 by Omar M. Amin, B.Sc., M.S., Ph.D.; USA
(Explore Issue: Volume 12, Number 6)

Neurocutaneous syndrome (NCS), a newly discovered toxicity disorder, is characterized by neurological sensations, pain, depleted energy and memory loss as well as itchy cutaneous lesions which may invite various opportunistic infections. Components in the calcium hydroxide dental sealants Dycal, Life and Sealapex have been identified as sources of the observed symptoms. Sulfonamide and neurological toxicity issues are discussed and three case histories are presented. Additional notes on zinc oxide, Fynal, IRM and Sultan U/P sealers are also included. Diagnostic and management protocols at the Parasitology Center, Inc. (PCI) are proposed.

The original description of the neurocutaneous syndrome (NCS) was “introductory in nature.” Examination of many NCS patients and a careful study of their symptoms, exposures, clinical conditions and histories made it possible to identify the underlying cause of the syndrome and proceed with its management.

Patients were personally evaluated and their clinical history, records, symptomology and exposures carefully examined. Specimens provided or collected at the Parasitology Center, Inc. (PCI) were studied. An NCS status was only determined based on symptoms and determination that one or more of the suspect sealers have been used on prior dates. Sensitivity to sulfa and elevated levels of sulfa in the blood were used as a confirmation of sulfonamide toxicity. Continuing patients follow our recommendations for dental rehabilitation, extraction of suspect liner(s), and replacement with ethyltoluene sulfonomide (ETS) and zinc oxide free sealants. A list of vitamin/mineral supplements for patient use during the transitional period and another list of substitute sealants are provided. Patients are followed up to monitor and insure the resolution of symptoms.